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CIB-L43

CAT: 0013-GTR19249174-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249174-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CIB-L43 is a potent, orally bioavailable TRBP inhibitor (K_D = 4.78 nM) that suppresses oncogenic miR-21 biogenesis. This action upregulates PTEN and Smad7, blocking AKT and TGF-β pathways to inhibit hepatocellular carcinoma cell proliferation and migration in vitro.
CAS Number
1082942-70-8
Product Name Alternative
CIBL43
Field of Research
Cell Biology, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.64% (May vary between batches)
Solubility
DMSO:5 mg/mL (16.43 mM)
Smiles
O=C (O) C=1SC (=NC1C) C=2C=CC (=CC2) N3CCOCC3
Molecular Formula
C15H16N2O3S
Molecular Weight
304.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-Methyl-2-(4-morpholin-4-ylphenyl)-1,3-thiazole-5-carboxylic acid
CAS Number1082942-70-8
PubChem CID28343014
IUPAC Name4-methyl-2-(4-morpholin-4-ylphenyl)-1,3-thiazole-5-carboxylic acid
Molecular FormulaC15H16N2O3S
Molecular Weight304.4
XLogP2.6
Topological Polar Surface Area90.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity368
SMILES
CC1=C(SC(=N1)C2=CC=C(C=C2)N3CCOCC3)C(=O)O
InChI
InChI=1S/C15H16N2O3S/c1-10-13(15(18)19)21-14(16-10)11-2-4-12(5-3-11)17-6-8-20-9-7-17/h2-5H,6-9H2,1H3,(H,18,19)
InChIKey
IOTJAUCPIIEIOF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-Methyl-2-(4-morpholin-4-ylphenyl)-1,3-thiazole-5-carboxylic acid
CAS: 1082942-70-8
CID: 28343014
Formula: C15H16N2O3S
MW: 304.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight304.4
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass304.08816355
Monoisotopic Mass304.08816355
Topological Polar Surface Area90.9 Ų
Heavy Atom Count21
Formal Charge0
Complexity368
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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