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Mitoguazone

CAT: 0013-GTR19244106-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19244106-01Size:1 g
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Description
Mitoguazone (Methylglyoxal-bis (guanylhydrazone) ) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment.
CAS Number
459-86-9
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: H2O : 50 mg/mL (271.44 mM; ultrasonic and adjust pH to 9 with HCl) DMSO : 8.33 mg/mL (45.22 mM; Ultrasonic (<60°C)
Smiles
C\C (\C=N\NC (N) =N) =N/NC (N) =N
Molecular Formula
C5H12N8
Molecular Weight
184.2
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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