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Mitoguazone

CAT: 0804-HY-106634-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106634-01Size:5 mg
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Description
Mitoguazone (Methylglyoxal-bis (guanylhydrazone) ) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment[1][2][3][4].
CAS Number
459-86-9
Product Name Alternative
Methylglyoxal-bis (guanylhydrazone) ; MGBG; Methyl-GAG
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HIV
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/mitoguazone.html
Purity
99.33
Solubility
DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic; adjust pH to 9 with HCl)
Smiles
CC(/C=N/NC(N)=N)=N\NC(N)=N
Molecular Formula
C5H12N8
Molecular Weight
184.20
Precautions
H302, H315, H319, H335
References & Citations
[1]J Rizzo, et al. Pharmacokinetic Profile of Mitoguazone (MGBG) in Patients With AIDS Related non-Hodgkin's Lymphoma. Invest New Drugs. 1996;14 (2) :227-34.|[2]K Davidson, et al. Mitoguazone Induces Apoptosis via a p53-independent Mechanism. Anticancer Drugs. 1998 Aug;9 (7) :635-40.|[3]Xia Jin, et al. Inhibition of HIV Expression and Integration in Macrophages by Methylglyoxal-Bis-Guanylhydrazone. J Virol. 2015 Nov;89 (22) :11176-89.|[4]A M Levine, et al. Mitoguazone Therapy in Patients With Refractory or Relapsed AIDS-related Lymphoma: Results From a Multicenter Phase II Trial. J Clin Oncol. 1997 Mar;15 (3) :1094-103.|[5]R Amlacher, et al. Influence of Leukemia P388 on the Pharmacokinetics of Mitoguazone in B6D2F1 Mice. Pharmazie. 1990 May;45 (5) :364-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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