CPG-52364

• Description:

  CPG-52364 (compound 2) is a TLR9 antagonist. CPG-52364 inhibits the HEK293-hTLR9 cell with an IC50 value of 4.6 nM[1].

• UNSPSC:

  12352005

• Target:

  Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cpg-52364.html

• Purity:

  98.49

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CN1CCN(C2=CC=C(C3=NC(NCCN4CCOCC4)=C5C=C(OC)C(OC)=CC5=N3)C=C2)CC1

• Molecular Formula:

  C27H36N6O3

• Molecular Weight:

  492.61

• References & Citations:

  [1]Manabu Watanabe, et al. Dihydropyrrolo[2,3-d]pyrimidines: Selective Toll-Like Receptor 9 Antagonists from Scaffold Morphing Efforts. ACS Med Chem Lett. 2014, 5, 11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1093135-60-4]