Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2
CAT:
804-HY-P10215
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2
- UNSPSC Description: Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC50 values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively[1].
- Target Antigen: Parasite
- Type: Peptides
- Related Pathways: Anti-infection
- Applications: COVID-19-immunoregulation
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/ac-cpg-thr-ala-ala-co-asp-cpg-nh2.html
- Solubility: 10 mM in DMSO
- Smiles: CC(N[C@@H](C1CCCC1)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N[C@H](C(C(N[C@H](C(N[C@@H](C2CCCC2)C(N)=O)=O)CC(O)=O)=O)=O)C)=O)C)=O)=O)=O
- Molecular Weight: 695.76
- References & Citations: [1]Legru A, et al. Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1[J]. European Journal of Medicinal Chemistry, 2024: 116308.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported