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TT-012

CAT: 0013-GTR19243557-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19243557-01Size:1 g
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Description
TT-012 specifically binds to dynamic MITF and destroys the latter's dimer formation and DNA-binding ability. TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells. TT-012 inhibits the growth of high-MITF melanoma cells, and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models.
CAS Number
1164471-33-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (286.25 mM; Ultrasonic)
Smiles
N (C (/C=C/C1=CC=CO1) =O) C=2N=C (NC (/C=C/C3=CC=CO3) =O) C=CC2
Molecular Formula
C19H15N3O4
Molecular Weight
349.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

(2e,2'e)-N,N'-(pyridine-2,6-diyl)bis(3-(furan-2-yl)acrylamide)
CAS Number1164471-33-3
PubChem CID2165557
IUPAC Name(E)-3-(furan-2-yl)-N-[6-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]-2-pyridinyl]prop-2-enamide
Molecular FormulaC19H15N3O4
Molecular Weight349.3
XLogP2.2
Topological Polar Surface Area97.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity503
SMILES
C1=CC(=NC(=C1)NC(=O)/C=C/C2=CC=CO2)NC(=O)/C=C/C3=CC=CO3
InChI
InChI=1S/C19H15N3O4/c23-18(10-8-14-4-2-12-25-14)21-16-6-1-7-17(20-16)22-19(24)11-9-15-5-3-13-26-15/h1-13H,(H2,20,21,22,23,24)/b10-8+,11-9+
InChIKey
YUFJMFXVUUMVCA-GFULKKFKSA-N
Chemical Structure
2D Structure
2D structure of (2e,2'e)-N,N'-(pyridine-2,6-diyl)bis(3-(furan-2-yl)acrylamide)
CAS: 1164471-33-3
CID: 2165557
Formula: C19H15N3O4
MW: 349.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight349.3
XLogP32.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass349.10625597
Monoisotopic Mass349.10625597
Topological Polar Surface Area97.4 Ų
Heavy Atom Count26
Formal Charge0
Complexity503
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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