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DSP-0390

CAT: 0013-GTR19243213-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19243213-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DSP-0390 is an orally bioavailable small molecule inhibitor of emopamil binding protein (EBP), a key enzyme in cholesterol biosynthesis. By blocking de novo cholesterol production, it selectively targets proliferating glioblastoma (GBM) cells, demonstrating potent antitumor efficacy in both in vitro assays and human GBM xenograft models.
CAS Number
2376765-57-8
Smiles
CC1 (C) [C@@]2 (CC3 (CO[C@]2 (C=4C (O1) =CC (Cl) =CC4) [H]) CCN (CCN5C=CN=C5) CC3) [H]
Molecular Formula
C23H30ClN3O2
Molecular Weight
415.96
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

RB55ZW48XG

EBP Inhibitor DSP-0390 is an orally bioavailable inhibitor of emopamil-binding protein (EBP), with potential antineoplastic activity. Upon oral administration, EBP inhibitor DSP-0390 targets, binds to and inhibits the activity of EBP. This inhibits EBP-mediated de novo cholesterol synthesis. As cholesterol is essential for tumor cell proliferation and survival, this inhibits tumor cell proliferation. The inhibition of EBP also results in the accumulation of its substrates zymostenol and zymosterol, and autophagy in tumor cells. EBP, a non-glycosylated type I integral membrane protein of endoplasmic reticulum, plays an important role in cholesterol biosynthesis, autophagy and oligodendrocyte formation, and is overexpressed in certain tumors.

CAS Number2376765-57-8
PubChem CID154975891
IUPAC Name(4aR,10bR)-8-chloro-1'-(2-imidazol-1-ylethyl)-5,5-dimethylspiro[2,4,4a,10b-tetrahydropyrano[3,2-c]chromene-3,4'-piperidine]
Molecular FormulaC23H30ClN3O2
Molecular Weight416.0
XLogP3.3
Topological Polar Surface Area39.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count29
Formal Charge0
Complexity580
SMILES
CC1([C@@H]2CC3(CCN(CC3)CCN4C=CN=C4)CO[C@H]2C5=C(O1)C=C(C=C5)Cl)C
InChI
InChI=1S/C23H30ClN3O2/c1-22(2)19-14-23(5-8-26(9-6-23)11-12-27-10-7-25-16-27)15-28-21(19)18-4-3-17(24)13-20(18)29-22/h3-4,7,10,13,16,19,21H,5-6,8-9,11-12,14-15H2,1-2H3/t19-,21+/m1/s1
InChIKey
QKAZUVQTHFXMLS-CTNGQTDRSA-N
Chemical Structure
2D Structure
2D structure of RB55ZW48XG
CAS: 2376765-57-8
CID: 154975891
Formula: C23H30ClN3O2
MW: 416.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight416.0
XLogP33.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass415.2026549
Monoisotopic Mass415.2026549
Topological Polar Surface Area39.5 Ų
Heavy Atom Count29
Formal Charge0
Complexity580
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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