Products for Research Use Only
RegisterLogin

GNS-1481

CAT: 0013-GTR19242260-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19242260-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GNS-1481 is a selective small molecule inhibitor designed to target the EGFR T790M resistance mutation. It is a research tool for studying resistance mechanisms in non-small cell lung cancer (NSCLC) and has demonstrated activity in both biochemical and cellular assays.
CAS Number
1903008-81-0
Smiles
O=C (C=C) NC1=CC (NC2=NC=CC (=N2) N3N=C (C (=C3) CN (C) C) C4CC4) =C (OC) C=C1N5CCOCC5
Molecular Formula
C27H34N8O3
Molecular Weight
518.61
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(5-(4-(3-cyclopropyl-4-((dimethylamino)methyl)-1H-pyrazol-1-yl)pyrimidin-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide
CAS Number1903008-81-0
PubChem CID121269056
IUPAC NameN-[5-[[4-[3-cyclopropyl-4-[(dimethylamino)methyl]pyrazol-1-yl]pyrimidin-2-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl]prop-2-enamide
Molecular FormulaC27H34N8O3
Molecular Weight518.6
XLogP2.3
Topological Polar Surface Area110
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Heavy Atom Count38
Formal Charge0
Complexity792
SMILES
CN(C)CC1=CN(N=C1C2CC2)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N5CCOCC5)OC
InChI
InChI=1S/C27H34N8O3/c1-5-25(36)29-20-14-21(23(37-4)15-22(20)34-10-12-38-13-11-34)30-27-28-9-8-24(31-27)35-17-19(16-33(2)3)26(32-35)18-6-7-18/h5,8-9,14-15,17-18H,1,6-7,10-13,16H2,2-4H3,(H,29,36)(H,28,30,31)
InChIKey
SEKXPOMGSBSXQJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(5-(4-(3-cyclopropyl-4-((dimethylamino)methyl)-1H-pyrazol-1-yl)pyrimidin-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide
CAS: 1903008-81-0
CID: 121269056
Formula: C27H34N8O3
MW: 518.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight518.6
XLogP32.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Exact Mass518.27538698
Monoisotopic Mass518.27538698
Topological Polar Surface Area110 Ų
Heavy Atom Count38
Formal Charge0
Complexity792
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19199949-01MI-1481
GTR18144667Adenovirus Antibody [1481]
GTR19226994-01Compound 1481-0011
GTR19055819GNS Peptide
GTR17904406-01GNS Antibody
GTR18137496GNS Antibody
GTR18582506-01GNS Antibody
GTR18149637GNS Antibody
GTR17936017GNS Antibody
GTR17904407-01GNS Antibody

Alternative Products

CatalogName
T202290-01GNS-1481
T24463-01MI-1481
T131636-01Compound 1481-0011
35-493Adenovirus Antibody [1481]
MBS9127677-01GNS
33-780S100A4 Antibody [S100A4/1481]
MBS8505649-01GNS Antibody
MBS3232654-01GNS Peptide
509925GNS discontinued
TS404458P5GNS CytoSection

Popular Products