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PROTAC SMARCA2/4-degrader-2

CAT: 0013-GTR19238842-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19238842-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Compound I-431 (SMARCA2/4-degrader-2) is a potent PROTAC that effectively degrades SMARCA2 and SMARCA4 proteins. In A549 cell studies, it achieves over 90% degradation (Dmax%) with DC50 values below 100 nM within 24 hours, making it a valuable tool for probing SWI/SNF complex function in cancer research.
CAS Number
2568277-76-7
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) [C@H]5CC[C@H] (C (N[C@H] (C (=O) N6[C@H] (C (NCC7=C (C (N (C) C) =O) C=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (O) C6) C (C) (C) C) =O) CC5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C52H64N12O6S
Molecular Weight
985.21
Storage Conditions
-20°C
Notes
For research use only.

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