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HDAC3-IN-4

CAT: 0013-GTR19237719-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19237719-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC3-IN-4 is a potent, orally bioavailable, and selective HDAC3 inhibitor (IC50 = 89 nM) that promotes PD-L1 degradation via lysosomal cathepsin B modulation (DC50 = 5.7 μM) . Its selectivity over other HDAC isoforms supports its utility in cancer immunotherapy research, both in vitro and in vivo, for investigating immune checkpoint regulation.
CAS Number
2988762-46-3
Field of Research
Epigenetics & Chromatin
Smiles
O=C (NCC1=CC=C (C=C1) C (=O) NNCCC) C2=NC=C (S2) CNC=3C=CC=CC3
Molecular Formula
C22H25N5O2S
Molecular Weight
423.53
Storage Conditions
-20°C
Notes
For research use only.

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