REM127

CAT: 0013-GTR19236489-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19236489-01Size:25 mg

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Description

REM127 is a neuroprotective small molecule that modulates calcium homeostasis, countering tau-induced imbalances in cellular models. It crosses the blood-brain barrier and has shown therapeutic benefits in Alzheimer's disease animal models, ameliorating cognitive deficits and slowing amyloid-beta and tau pathology progression.

CAS Number

1417823-67-6

Field of Research

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Smiles

ClC=1C=CC (=CC1) C2=NSC (=N2) N3CCN (CCC=4C=CC=CC4Cl) CC3

Molecular Formula

C20H20Cl2N4S

Molecular Weight

419.37

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

3-(4-Chlorophenyl)-5-[4-[2-(2-chlorophenyl)ethyl]piperazin-1-yl]-1,2,4-thiadiazole

CAS Number	1417823-67-6
PubChem CID	71186343
IUPAC Name	3-(4-chlorophenyl)-5-[4-[2-(2-chlorophenyl)ethyl]piperazin-1-yl]-1,2,4-thiadiazole
Molecular Formula	C20H20Cl2N4S
Molecular Weight	419.4
XLogP	5.9
Topological Polar Surface Area	60.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	27
Formal Charge	0
Complexity	455

SMILES

C1CN(CCN1CCC2=CC=CC=C2Cl)C3=NC(=NS3)C4=CC=C(C=C4)Cl

InChI

InChI=1S/C20H20Cl2N4S/c21-17-7-5-16(6-8-17)19-23-20(27-24-19)26-13-11-25(12-14-26)10-9-15-3-1-2-4-18(15)22/h1-8H,9-14H2

InChIKey

YWJORACHBFMAHI-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1417823-67-6

CID: 71186343

Formula: C20H20Cl2N4S

MW: 419.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	419.4
XLogP3	5.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	418.0785732
Monoisotopic Mass	418.0785732
Topological Polar Surface Area	60.5 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	455
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
T88556-01	REM127

REM127

Chemical Information

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