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MD-265

CAT: 0013-GTR19241444-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241444-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MD-265 is a PROTAC small molecule that induces MDM2 degradation, activating the p53 pathway in wild-type p53 cancer models. It has demonstrated potent anti-tumor activity, achieving complete tumor regression and enhancing survival in leukemic mouse models, supporting its use in oncology research.
CAS Number
2415160-21-1
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
O=C1[C@@]2 (C3 (N[C@@H] (C (N[C@@H]4CC[C@@H] (C (=O) N5CCC (C#CC6=C7C (C (=O) N (C7) C8C (=O) NC (=O) CC8) =CC=C6) CC5) CC4) =O) [C@@H]2C9=C (F) C (Cl) =CC=C9) CCCCC3) C=%10C (N1) =CC (Cl) =CC%10
Molecular Formula
C50H51Cl2FN6O6
Molecular Weight
921.88
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-(4-((2-(2,6-dioxopiperidin-3-YL)-1-oxoisoindolin-4-YL)ethynyl)piperidine-1-carbonyl)cyclohexyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide
CAS Number2415160-21-1
PubChem CID146461082
Molecular FormulaC50H51Cl2FN6O6
Molecular Weight921.9
XLogP5.7
Topological Polar Surface Area157
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count65
Formal Charge0
Complexity1970
SMILES
C1CCC2(CC1)[C@@]3([C@H]([C@@H](N2)C(=O)NC4CCC(CC4)C(=O)N5CCC(CC5)C#CC6=C7CN(C(=O)C7=CC=C6)C8CCC(=O)NC8=O)C9=C(C(=CC=C9)Cl)F)C1=C(C=C(C=C1)Cl)NC3=O
InChI
InChI=1S/C50H51Cl2FN6O6/c51-31-14-17-36-38(26-31)55-48(65)50(36)41(34-8-5-9-37(52)42(34)53)43(57-49(50)22-2-1-3-23-49)45(62)54-32-15-12-30(13-16-32)46(63)58-24-20-28(21-25-58)10-11-29-6-4-7-33-35(29)27-59(47(33)64)39-18-19-40(60)56-44(39)61/h4-9,14,17,26,28,30,32,39,41,43,57H,1-3,12-13,15-16,18-25,27H2,(H,54,62)(H,55,65)(H,56,60,61)/t30?,32?,39?,41-,43+,50+/m0/s1
InChIKey
ISQCXAWAHDJCRH-AQEUJYEFSA-N
Chemical Structure
2D Structure
2D structure of (3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-(4-((2-(2,6-dioxopiperidin-3-YL)-1-oxoisoindolin-4-YL)ethynyl)piperidine-1-carbonyl)cyclohexyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide
CAS: 2415160-21-1
CID: 146461082
Formula: C50H51Cl2FN6O6
MW: 921.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight921.9
XLogP35.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass920.3231169
Monoisotopic Mass920.3231169
Topological Polar Surface Area157 Ų
Heavy Atom Count65
Formal Charge0
Complexity1970
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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