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JBJ-07-149

CAT: 0013-GTR19241376-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241376-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JBJ-07-149 is a potent, selective inhibitor of the EGFRL858R/T790M mutant (IC50 = 1.1 nM) . It demonstrates anti-proliferative activity in Ba/F3 cells, with efficacy significantly enhanced in combination with Cetuximab. This compound is also a key chemical precursor for synthesizing the PROTAC molecule [DDC-01-163], supporting targeted protein degradation research.
CAS Number
2140807-58-3
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O=C1C2=CC (=CC=C2CN1C (C (=O) NC3=NC=CS3) C=4C=CC=CC4) C=5C=NC (=CC5) N6CCNCC6
Molecular Formula
C28H26N6O2S
Molecular Weight
510.61
Storage Conditions
-20°C
Notes
For research use only.

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