Fibronectin Adhesion-promoting Peptide (TFA)

Fibronectin Adhesion-promoting Peptide (TFA)

• UNSPSC Description: Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells[1][2][3].
• Target Antigen: Others
• Type: Peptides
• Related Pathways: Others
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/fibronectin-adhesion-promoting-peptide-tfa.html
• Solubility: 10 mM in DMSO
• Smiles: CC[C@H](C)[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@H]1N(C([C@H]2N(C([C@H](CCC(N)=O)NC([C@H](CC3=CNC4=C3C=CC=C4)N)=O)=O)CCC2)=O)CCC1)=O)=O)=O)=O.OC(C(F)(F)F)=O
• Molecular Weight: 1137.22
• References & Citations: [1]Hoesli CA, et al. A fluorophore-tagged RGD peptide to control endothelial cell adhesion to micropatterned surfaces. Biomaterials. 2014 Jan;35(3):879-90.|[2]Chollet C, et al. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci. 2012 Dec;12(12):1648-59.|[3]Lei J, Murphy WL, et al. Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. Bioconjug Chem. 2018 Apr 18;29(4):878-884.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported