Fibronectin, Human

• Description:

  Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. Fibronectin Protein, Human is the recombinant human-derived Fibronectin protein, expressed by E. coli, with tag free.

• Product Name Alternative:

  Fibronectin Protein, Human, Human, E. coli

• UNSPSC:

  12352202

• Type:

  Recombinant Proteins

• Assay Protocol:

  https://www.medchemexpress.com/cytokines/fibronectin-protein-human.html

• Purity:

  98.0

• Smiles:

  PTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPS&AIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPST

• Molecular Formula:

  2335 (Gene_ID) P02751-1 (P1270-S1546&A1721-T2016) (Accession)

• Molecular Weight:

  Approximately 63 kDa

• References & Citations:

  [1]Patten J, Wang K. Fibronectin in development and wound healing. Adv Drug Deliv Rev. 2021 Mar;170:353-368.|[2]Lenselink EA. Role of fibronectin in normal wound healing. Int Wound J. 2015 Jun;12 (3) :313-6. doi: 10.1111/iwj.12109. Epub 2013 Jun 7.|[3]Bielefeld K A, et al. Fibronectin and β-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing[J]. Journal of Biological Chemistry, 2011, 286 (31) : 27687-27697.|[4]Shi F, et al. MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin[J]. Journal of cell science, 2011, 124 (23) : 4039-4050.|[5]Lefcort F, et al. Regulation of expression of fibronectin and its receptor, α5β1, during development and regeneration of peripheral nerve[J]. Development, 1992, 116 (3) : 767-782.|[6]Clark RA, et al. Blood vessel fibronectin increases in conjunction with endothelial cell proliferation and capillary ingrowth during wound healing. J Invest Dermatol. 1982 Nov;79 (5) :269-76.|[7]Oyama F, et al. Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors. J Biol Chem. 1989 Jun 25;264 (18) :10331-4.|[8]Yi M, Ruoslahti E. A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis. Proc Natl Acad Sci U S A. 2001 Jan 16;98 (2) :620-4.|[9]Quirós J, et al. Beneficial effect of fibronectin administration on chronic nephritis in rats. Arthritis Rheum. 1990 May;33 (5) :685-92.|[10]Su MT, et al. Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice. Int Immunol. 2021 Jul 23;33 (8) :447-458.|[11]Sottile J, et al. Fibronectin matrix assembly enhances adhesion-dependent cell growth. J Cell Sci. 1998 Oct;111 (Pt 19) :2933-43.|[12]Su MT, et al. Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice. Int Immunol. 2021 Jul 23;33 (8) :447-458.

• Shipping Conditions:

  Room temperature in continental US; may vary elsewhere.

• Storage Conditions:

  Stored at -20°C for 2 years

• Scientific Category:

  Recombinant Proteins