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TYA-018

CAT: 0013-GTR19233391-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19233391-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TYA-018 is a selective, orally bioavailable HDAC6 inhibitor developed for cardiovascular research. It exhibits cardioprotective effects by mitigating sarcomere damage and reducing Nppb expression, making it a valuable tool for in vivo and in vitro studies of dilated cardiomyopathy and heart failure mechanisms.
CAS Number
2653254-31-8
Product Name Alternative
HDAC6, TYA 018, TYA018
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Purity
98.64% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.59 mM) ; DMSO:80 mg/mL (183.96 mM)
Smiles
O=S (=O) (N (C=1C=CC=C (Cl) C1) CC2=NC=C (S2) C3=NN=C (O3) C (F) F) CC
Molecular Formula
C15H13ClF2N4O3S2
Molecular Weight
434.87
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(3-Chlorophenyl)-N-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)thiazol-2-yl)methyl)ethanesulfonamide
CAS Number2653254-31-8
PubChem CID156525534
IUPAC NameN-(3-chlorophenyl)-N-[[5-[5-(difluoromethyl)-1,3,4-oxadiazol-2-yl]-1,3-thiazol-2-yl]methyl]ethanesulfonamide
Molecular FormulaC15H13ClF2N4O3S2
Molecular Weight434.9
XLogP2.8
Topological Polar Surface Area126
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Heavy Atom Count27
Formal Charge0
Complexity598
SMILES
CCS(=O)(=O)N(CC1=NC=C(S1)C2=NN=C(O2)C(F)F)C3=CC(=CC=C3)Cl
InChI
InChI=1S/C15H13ClF2N4O3S2/c1-2-27(23,24)22(10-5-3-4-9(16)6-10)8-12-19-7-11(26-12)14-20-21-15(25-14)13(17)18/h3-7,13H,2,8H2,1H3
InChIKey
DAMJZODYLBMFHQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-Chlorophenyl)-N-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)thiazol-2-yl)methyl)ethanesulfonamide
CAS: 2653254-31-8
CID: 156525534
Formula: C15H13ClF2N4O3S2
MW: 434.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight434.9
XLogP32.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass434.0085667
Monoisotopic Mass434.0085667
Topological Polar Surface Area126 Ų
Heavy Atom Count27
Formal Charge0
Complexity598
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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