SP-2-225

CAT: 0013-GTR19231024-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19231024-02Size:50 mg

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Description

SP-2-225 is a selective HDAC6 inhibitor that increases cancer antigen production and boosts macrophage-mediated cross-presentation to T cells. This mechanism has been shown to reduce tumor growth in syngeneic SM1 melanoma models, supporting its use in immuno-oncology research for studying HDAC6's role in antitumor immunity.

CAS Number

2364448-93-9

Field of Research

Epigenetics & Chromatin, Molecular Biology

Smiles

CC1=C (C=CC=C1COC2=C (C) C=C (CNCCCCCC (NO) =O) C=C2) C3=CC=CC=C3

Molecular Formula

C28H34N2O3

Molecular Weight

446.58

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

N-hydroxy-6-[[3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methylamino]hexanamide

CAS Number	2364448-93-9
PubChem CID	142622677
IUPAC Name	N-hydroxy-6-[[3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methylamino]hexanamide
Molecular Formula	C28H34N2O3
Molecular Weight	446.6
XLogP	4.9
Topological Polar Surface Area	70.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	12
Heavy Atom Count	33
Formal Charge	0
Complexity	551

SMILES

CC1=C(C=CC(=C1)CNCCCCCC(=O)NO)OCC2=C(C(=CC=C2)C3=CC=CC=C3)C

InChI

InChI=1S/C28H34N2O3/c1-21-18-23(19-29-17-8-4-7-14-28(31)30-32)15-16-27(21)33-20-25-12-9-13-26(22(25)2)24-10-5-3-6-11-24/h3,5-6,9-13,15-16,18,29,32H,4,7-8,14,17,19-20H2,1-2H3,(H,30,31)

InChIKey

UTCSUALKFUTHBF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2364448-93-9

CID: 142622677

Formula: C28H34N2O3

MW: 446.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	446.6
XLogP3	4.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	12
Exact Mass	446.25694295
Monoisotopic Mass	446.25694295
Topological Polar Surface Area	70.6 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	551
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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MBS5821028	SP-2-225
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KFA99148-01	MCI 225
T28807-01	SLUPP-225
MBS370006-01	BCA-225
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SP-2-225

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