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Kushenol K

CAT: 0804-HY-117010Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117010Size:1 Each
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Description
Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM) [2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].
CAS Number
101236-49-1
UNSPSC
12352005
Target
Cytochrome P450; HSV; SGLT
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/kushenol-k.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1O)=C(C2=O)C(O[C@H](C(C=CC(O)=C3)=C3O)[C@@H]2O)=C1C[C@H](C(C)=C)CCC(C)(O)C
Molecular Formula
C26H32O8
Molecular Weight
472.53
References & Citations
[1]Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.|[2]E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61 (12) :1552-4.|[3]Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15 (10) :3445-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP3; HSV-2; SGLT1; SGLT2

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