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Kushenol E

CAT: 0804-HY-N2463-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2463-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity[1].
CAS Number
99119-72-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kushenol-e.html
Purity
96.0
Solubility
10 mM in DMSO
Smiles
O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=C(C/C=C(C)\C)C(O)=C(C/C=C(C)\C)C(O)=C13
Molecular Formula
C25H28O6
Molecular Weight
424.49
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kwon M, et al. Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. J Enzyme Inhib Med Chem. 2019 Dec;34 (1) :1481-1488.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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