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ACTH (1-17) (TFA)

CAT: 0804-HY-P1545A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1545A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACTH (1-17) TFA, an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.
Product Name Alternative
α1-17-ACTH (TFA)
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/acth-1-17-tfa.html
Purity
99.79
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
CSCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)=O)C(C)C)=O)=O)CCCCN)=O)=O)CC2=CNC3=C2C=CC=C3)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O)CCC(O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CC6=CC=C(O)C=C6)=O)CO)=O.O=C(O)C(F)(F)F
Molecular Formula
C95H145N29O23S.C2HF3O2
Molecular Weight
2207.43
References & Citations
[1]Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand) . 1999 Nov;45 (7) :1029-34.|[2]Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19 (8) :361-3.|[3]Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34 (8) :1191-6.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC1R

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