ACTH (1-17) (TFA)

• UNSPSC Description:

  ACTH (1-17) TFA, an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.

• Target Antigen:

  Melanocortin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Neurological Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/acth-1-17-tfa.html

• Purity:

  99.19

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  CSCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)=O)C(C)C)=O)=O)CCCCN)=O)=O)CC2=CNC3=C2C=CC=C3)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O)CCC(O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CC6=CC=C(O)C=C6)=O)CO)=O.O=C(O)C(F)(F)F

• Molecular Weight:

  2207.43

• References & Citations:

  [1]Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1029-34.|[2]Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3.|[3]Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34(8):1191-6.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported