ACTH (1-17)

• Description:

  ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.

• Product Name Alternative:

  α1-17-ACTH

• UNSPSC:

  12352209

• Target:

  Melanocortin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Neurological Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/ACTH_1-17.html

• Solubility:

  H2O

• Smiles:

  O=C (N[C@@H] (CC1=CC=C (C=C1) O) C (N[C@@H] (CO) C (N[C@@H] (CCSC) C (N[C@@H] (CCC (O) =O) C (N[C@@H] (CC2=CNC=N2) C (N[C@@H] (CC3=CC=CC=C3) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (CC4=CNC5=CC=CC=C45) C (NCC (N[C@@H] (CCCCN) C (N6[C@@H] (CCC6) C (N[C@@H] (C (C) C) C (NCC (N[C@@H] (CCCCN) C (N[C@@H] (CCCCN) C (N[C@@H] (CCCNC (N) =N) C (O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) [C@H] (CO) N

• Molecular Formula:

  C95H145N29O23S

• Molecular Weight:

  2093.41

• References & Citations:

  [1]Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand) . 1999 Nov;45 (7) :1029-34.|[2]Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19 (8) :361-3.|[3]Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34 (8) :1191-6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  MC1R

• CAS Number:

  7266-47-9