PTK7/β-catenin-IN-2

CAT: 0013-GTR19234712-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19234712-01Size:50 mg

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Description

PTK7/β-catenin-IN-2 (04967) is a dual inhibitor of the PTK7/β-catenin interaction and the p53-MDM2 binding, with IC50 values of 5.6 μM and 157.1 μM, respectively. It disrupts Wnt/β-catenin signaling, supporting its use in anticancer research for inhibiting Wnt-dependent cell proliferation in vitro.

CAS Number

902434-29-1

Field of Research

Signal Transduction, Stem Cell & Developmental Biology

Smiles

CC=1N2C (=CC (=N2) C3=CC=C (Cl) C=C3) N=C (C) C1CCC (NCCCN4CCN (CC4) C5=CC (Cl) =CC=C5) =O

Molecular Formula

C30H34Cl2N6O

Molecular Weight

565.54

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

PTK7/beta-catenin-IN-2

CAS Number	902434-29-1
PubChem CID	46255685
IUPAC Name	3-[2-(4-chlorophenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]-N-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]propanamide
Molecular Formula	C30H34Cl2N6O
Molecular Weight	565.5
XLogP	5.5
Topological Polar Surface Area	65.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	9
Heavy Atom Count	39
Formal Charge	0
Complexity	775

SMILES

CC1=C(C(=NC2=CC(=NN12)C3=CC=C(C=C3)Cl)C)CCC(=O)NCCCN4CCN(CC4)C5=CC(=CC=C5)Cl

InChI

InChI=1S/C30H34Cl2N6O/c1-21-27(22(2)38-29(34-21)20-28(35-38)23-7-9-24(31)10-8-23)11-12-30(39)33-13-4-14-36-15-17-37(18-16-36)26-6-3-5-25(32)19-26/h3,5-10,19-20H,4,11-18H2,1-2H3,(H,33,39)

InChIKey

JVQFIVIGXOMNNB-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 902434-29-1

CID: 46255685

Formula: C30H34Cl2N6O

MW: 565.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	565.5
XLogP3	5.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	9
Exact Mass	564.2171151
Monoisotopic Mass	564.2171151
Topological Polar Surface Area	65.8 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	775
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T87274-01	PTK7/β-catenin-IN-2
HY-160493-01	PTK7/β-catenin-IN-6
HY-160488-01	PTK7/β-catenin-IN-1
527411-01	PTK7
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BF0315	PTK7 antibody
sc-100304	PTK7 (WW02)
573803-01	PTK7 (HRP)
573802-01	PTK7 (FITC)
502305	PTK7, NT

PTK7/β-catenin-IN-2

Chemical Information

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