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RGH-560

CAT: 0013-GTR19234692-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19234692-01Size:10 mg
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Description
RGH-560 (compound 53) is a potent and selective positive allosteric modulator of the α7 nicotinic acetylcholine receptor. It demonstrates favorable drug-like properties and robust efficacy in vivo, making it a valuable research tool for investigating cognitive deficits, such as those modeled in scopolamine-induced amnesia studies in mice.
CAS Number
2408799-43-7
Field of Research
Neuroscience
Smiles
C (NCC=1C=C2C (=CC1) N (C) C=C2) (=O) N3CC4 (OC=5C (C (=O) C4) =CC=C (F) C5) C3
Molecular Formula
C22H20FN3O3
Molecular Weight
393.41
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 156705614
CAS Number2408799-43-7
PubChem CID156705614
IUPAC Name7-fluoro-N-[(1-methylindol-5-yl)methyl]-4-oxospiro[3H-chromene-2,3'-azetidine]-1'-carboxamide
Molecular FormulaC22H20FN3O3
Molecular Weight393.4
XLogP2
Topological Polar Surface Area63.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count29
Formal Charge0
Complexity668
SMILES
CN1C=CC2=C1C=CC(=C2)CNC(=O)N3CC4(C3)CC(=O)C5=C(O4)C=C(C=C5)F
InChI
InChI=1S/C22H20FN3O3/c1-25-7-6-15-8-14(2-5-18(15)25)11-24-21(28)26-12-22(13-26)10-19(27)17-4-3-16(23)9-20(17)29-22/h2-9H,10-13H2,1H3,(H,24,28)
InChIKey
LXOXUGXUUINWLS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 156705614
CAS: 2408799-43-7
CID: 156705614
Formula: C22H20FN3O3
MW: 393.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight393.4
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass393.14886967
Monoisotopic Mass393.14886967
Topological Polar Surface Area63.6 Ų
Heavy Atom Count29
Formal Charge0
Complexity668
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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