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WH244

CAT: 0013-GTR19234118-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19234118-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WH244 is a potent and selective PROTAC degrader of BCL-2 and BCL-xL, with DC50 values of 7.4 nM and 0.6 nM, respectively. It induces target ubiquitination and proteasomal degradation, restoring apoptosis and demonstrating antitumor efficacy in cellular and in vivo cancer research models.
CAS Number
2941088-96-4
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
C (C1=C (CC[C@] (CN2CCN (C (CN3CCN (CC (N[C@H] (C (=O) N4[C@H] (C (N[C@@H] (C) C5=CC=C (C=C5) C6=C (C) N=CS6) =O) C[C@@H] (O) C4) [C@@] (C) (C) C) =O) CC3) =O) CC2) (C) C1) C7=CC=C (Cl) C=C7) N8CCN (CC8) C9=CC=C (C (NS (=O) (=O) C%10=CC (S (C (F) (F) F) (=O) =O) =C (N[C@H] (CCN%11[C@@]%12 (C[C@] (C%11) (OC%12) [H]) [H]) CSC%13=CC=CC=C%13) C=C%10) =O) C=C9
Molecular Formula
C83H105ClF3N13O11S4
Molecular Weight
1681.51
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
C04930WH244

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