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WH244

CAT: 0804-HY-161410-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-161410-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WH244 is a second generation BCL-2 and BCL-xL dual depressant (PROTAC). The primary activity of WH244 is the specific degradation of BCL-2 and BCL-xL proteins (BCL-xL: DC50=0.6 nM, BCL-2: DC50=7.4 nM). WH244 promotes their ubiquitination and subsequent proteasome degradation by targeting these proteins, thereby restoring the cell's apoptosis pathway. WH244 has good antitumor activity. (Pink: BCL-2/BCL-xL ligand ; Blue: E3 ligase ligand (HY-112078) ; Black: linker).
CAS Number
2941088-96-4
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wh244.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CN4CCN(CC(N5CCN(C[C@]6(C)CCC(C7=CC=C(Cl)C=C7)=C(CN8CCN(C9=CC=C(C(NS(C%10=CC(S(C(F)(F)F)(=O)=O)=C(N[C@@H](CSC%11=CC=CC=C%11)CCN%12C[C@@H]%13OC[C@H]%12C%13)C=C%10)(=O)=O)=O)C=C9)CC8)C6)CC5)=O)CC4)=O)C(C)(C)C)=O)=O)C)C=C2)SC=N1
Molecular Formula
C83H105ClF3N13O11S4
Molecular Weight
1681.51
References & Citations
[1]Nayak D, et al. Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL[J]. Nature communications, 2024, 15 (1) : 2743.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
C04930WH244

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