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L-2-Hydroxyglutaric acid

CAT: 0013-GTR19226867-02Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19226867-02Size:1 mg
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Description
L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized oncometabolite that acts as a substrate for L2HGDH. It functions as an inhibitor of histone demethylases and activates the mTOR-ATF4 signaling pathway. This small molecule is a valuable tool for research in cancer metabolism, epigenetics, and biosensor development in both in vitro and in vivo models.
CAS Number
13095-48-2
Field of Research
Epigenetics & Chromatin, Metabolism Research
Smiles
[C@H] (CCC (O) =O) (C (O) =O) O
Molecular Formula
C5H8O5
Molecular Weight
148.11
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

L-2-Hydroxyglutaric acid

(S)-2-hydroxyglutaric acid is a 2-hydroxyglutaric acid. It is a conjugate acid of a (S)-2-hydroxyglutarate(2-). It is an enantiomer of a (R)-2-hydroxyglutaric acid.

CAS Number13095-48-2
PubChem CID439939
IUPAC Name(2S)-2-hydroxypentanedioic acid
Molecular FormulaC5H8O5
Molecular Weight148.11
XLogP-1
Topological Polar Surface Area94.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count10
Formal Charge0
Complexity141
SMILES
C(CC(=O)O)[C@@H](C(=O)O)O
InChI
InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKey
HWXBTNAVRSUOJR-VKHMYHEASA-N
Chemical Structure
2D Structure
2D structure of L-2-Hydroxyglutaric acid
CAS: 13095-48-2
CID: 439939
Formula: C5H8O5
MW: 148.11
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight148.11
XLogP3-1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass148.03717335
Monoisotopic Mass148.03717335
Topological Polar Surface Area94.8 Ų
Heavy Atom Count10
Formal Charge0
Complexity141
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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