LC3-mHTT-IN-AN1

• CAS Number:

  486443-73-6

• UNSPSC Description:

  LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].

• Target Antigen:

  Atg8/LC3; ATTECs; Autophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy;PROTAC

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lc3-mhtt-in-1.html

• Purity:

  98.99

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O

• Molecular Weight:

  411.04

• References & Citations:

  [1]Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported