LC3-mHTT-IN-AN2

• CAS Number:

  7758-73-8

• UNSPSC Description:

  LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].

• Target Antigen:

  Atg8/LC3; ATTECs; Autophagy

• Type:

  Natural Products

• Related Pathways:

  Autophagy;PROTAC

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lc3-mhtt-in-2.html

• Purity:

  98.12

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  OC1=C2C(OC(C=C2C3=CC=CC=C3)=O)=CC(O)=C1

• Molecular Weight:

  254.24

• References & Citations:

  [1]Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported