MAP4K4-IN-3
CAT:
804-HY-125012-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MAP4K4-IN-3
- CAS Number: 1811510-58-3
- UNSPSC Description: MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].
- Target Antigen: MAP4K
- Type: Reference compound
- Related Pathways: MAPK/ERK Pathway
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/map4k4-in-3.html
- Purity: 99.15
- Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: NC1=NC=C(C2=CC(C3=CC=C(Cl)C=C3)=C(N)N=C2)C=N1
- Molecular Weight: 297.74
- References & Citations: [1]Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.|[2]Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61(7):3114-3125.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported