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MAC glucuronide α-hydroxy lactone-linked SN-38

CAT: 0013-GTR19224942-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19224942-01Size:100 mg
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Description
This cytotoxic drug linker incorporates a stabilized lactone form of the SN-38 metabolite, a potent topoisomerase I inhibitor. It demonstrates in vitro efficacy against hematological cancer cell lines such as L540cy and Ramos, with IC50 values of 99 and 105 ng/mL, respectively. This compound is a valuable tool for developing antibody-drug conjugates (ADCs) and studying targeted cancer therapies.
CAS Number
2246380-70-9
Field of Research
Pharmacology & Drug Discovery
Smiles
O=C1N2C (C=3C (C2) =C (CC) C=4C (N3) =CC=C (O) C4) =CC5=C1COC (=O) [C@]5 (OCN (C (OCC6=CC (NC (CN (C (CCN7C (=O) C=CC7=O) =O) C) =O) =C (O[C@@H]8O[C@H] (C (O) =O) [C@@H] (O) [C@H] (O) [C@H]8O) C=C6) =O) CCS (C) (=O) =O) CC
Molecular Formula
C50H54N6O20S
Molecular Weight
1091.06
Storage Conditions
-20°C
Notes
For research use only.

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Alternative Products

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T18722-01MAC glucuronide α-hydroxy lactone-linked SN-38
MBS3842871-01MAC glucuronide alpha-hydroxy lactone-linked SN-38
A18407-10MAC glucuronide α -hydroxy lactone-linked SN-38 10mg
A18407-5MAC glucuronide α -hydroxy lactone-linked SN-38 5mg
A18407-1MAC glucuronide α -hydroxy lactone-linked SN-38 1mg
A18407-25MAC glucuronide α -hydroxy lactone-linked SN-38 25mg
WPD38069-01Mac glucuronide phenol-linked sn-38
A18403-5MAC glucuronide phenol-linked SN-38 5mg
A18403-1MAC glucuronide phenol-linked SN-38 1mg
A18403-10MAC glucuronide phenol-linked SN-38 10mg

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