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CRIPGBM (chloride)

CAT: 0804-HY-115630-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115630-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs) . cRIPGBM (chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM (chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex) . cRIPGBM (chloride) exerts potent anti-tumor activity in vivo in animal models[1].
CAS Number
2361988-77-2
Product Name Alternative
(1S,3R)-RSL3
UNSPSC
12352005
Hazard Statement
H317, H320, H350, H373, H410
Target
Apoptosis; Caspase; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cripgbm-chloride.html
Purity
99.82
Solubility
DMSO : 25 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C2[N+](CC3=CC=C(F)C=C3)=C(C)N1CC4=CC=CC=C4)C5=C(C=CC=C5)C2=O.[Cl-]
Molecular Formula
C26H20ClFN2O2
Molecular Weight
446.90
Precautions
H317, H320, H350, H373, H410
References & Citations
[1]Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116 (13) :6435-6440.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; RIPK2

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