Propranolol (hydrochloride) (Standard)

• UNSPSC Description:

  Propranolol (hydrochloride) (Standard) is the analytical standard of Propranolol (hydrochloride). This product is intended for research and analytical applications. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

• Target Antigen:

  Adrenergic Receptor; Bacterial

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection;GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Neurological Disease; Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/propranolol-hydrochloride-standard.html

• Smiles:

  OC(CNC(C)C)COC1=CC=CC2=CC=CC=C12.Cl

• Molecular Weight:

  295.80

• References & Citations:

  [1]Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1|[2]Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73.|[3]Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.|[4]Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55.

• Shipping Conditions:

  Room temperature

• CAS Number:

  318-98-9