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Propranolol-d7

CAT: 0804-HY-B0573BSSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0573BSSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Propranolol-d7 is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
CAS Number
98897-23-5
UNSPSC
12352005
Hazard Statement
H302, H312, H372
Target
Adrenergic Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease; Cardiovascular Disease; Endocrinology
Purity
99.0
Solubility
DMSO : 100mg/mL (ultrasonic)
Smiles
OC(COC1=C2C=CC=CC2=CC=C1)CNC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
Molecular Formula
C16H14D7NO2
Molecular Weight
266.39
Precautions
H302, H312, H372
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70 (5) :1575-84. Epub 2006 Aug 1|[3]Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69 (4) :669-73.|[4]Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338.|[5]Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5 (1) :45-55.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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