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PROTAC BRD4 Degrader-10

CAT: 0013-GTR19222214-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19222214-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC BRD4 Degrader-10 (compound 8b) is a heterobifunctional degrader targeting BRD4 via VHL recruitment. It demonstrates potent degradation in PC3 prostate cancer cells with DC50 values of 1.3 nM and 18 nM when conjugated to STEAP1 and CLL1 antibodies, respectively, supporting targeted protein degradation research in oncology.
CAS Number
2417370-49-9
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
CC (OC (=O) O[C@@H]1C[C@H] (N (C1) C (=O) [C@@H] (NC (=O) COCCOCCOCCNC (=O) c1cc2N (Cc3c[nH]c4c3c (cn (C) c4=O) -c2cc1CS (C) (=O) =O) c1ncc (F) cc1F) C (C) (C) C) C (=O) NCc1ccc (cc1) -c1scnc1C) C (C) SS (C) (=O) =O
Molecular Formula
C59H71F2N9O15S4
Molecular Weight
1312.5
Storage Conditions
-20°C
Notes
For research use only.

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