Products for Research Use Only

PROTAC EGFR degrader 7

CAT: 0013-GTR19221084-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19221084-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC EGFR degrader 7 is a potent and selective CRBN-based degrader of EGFR L858R/T790M mutants, demonstrating a DC50 of 13.2 nM. It inhibits proliferation (IC50=46.82 nM), induces apoptosis and G2/M arrest in NCI-H1975 cells, showing promise for targeted NSCLC research both in vitro and in vivo.
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C46H48N10O6
Molecular Weight
836.94
Storage Conditions
-20°C
Notes
For research use only.