Products for Research Use Only
RegisterLogin

Polymyxin B1

CAT: 0804-HY-A0248A-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-A0248A-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B. Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment[1][2].
CAS Number
4135-11-9
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/polymyxin-b1.html
Purity
98.90
Solubility
1 M HCl : 10 mg/mL (ultrasonic; warming)
Smiles
O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@]1([H])[C@H](O)C)=O)CCN)=O)([H])CCN)=O)CC(C)C)[C@H](NC([C@@H](NC([C@@](CCNC1=O)([H])NC([C@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCC[C@@H](C)CC)=O)=O)=O)=O)=O)CCN)=O)CC2=CC=CC=C2
Molecular Formula
C56H98N16O13
Molecular Weight
1203.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Kwa AL, et al. Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections. Diagn Microbiol Infect Dis. 2008 Feb;60 (2) :163-7.|[2]Berglund NA, et al. Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: a molecular dynamics study. PLoS Comput Biol. 2015 Apr 17;11 (4) :e1004180.|[3]Tam VH, et al. In vitro potency of various polymyxin B components. Antimicrob Agents Chemother. 2011 Sep;55 (9) :4490-1.|[4]Alonso MA, et al. Compounds affecting membranes that inhibit protein synthesis in yeast. Antimicrob Agents Chemother. 1979 Dec;16 (6) :750-6.|[5]Sivanesan S, et al. Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats. J Nat Prod. 2017 Jan 27;80 (1) :225-229.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Natural Products
Clinical Information
Launched

Related Products

CatalogName
HY-N15099Polymyxin A2
HY-149179-01Polymyxin B
HY-P2954Polymyxin deacylase
HY-N15118Polymyxin P2
HY-N15117Polymyxin P1
HY-N15115Polymyxin D1
HY-N15114Polymyxin A1
HY-N15120Polymyxin T1
HY-N15119Polymyxin S1
HY-N14717Polymyxin M

Alternative Products

CatalogName
C3598-10Polymyxin B1
TN10927-01Polymyxin P1
T25972-01Polymyxin D2
T78685Polymyxin B
GTR19255646-01Polymyxin D1
T25971Polymyxin B2
TN10848-01Polymyxin T1
GTR19254551-01Polymyxin M
AR-P29817-01Polymyxin B3
JL58225-01Polymyxin B (Polymyxin B) ELISA Kit

Popular Products