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YZ129

CAT: 0013-GTR19217387-02Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217387-02Size:200 mg
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Description
YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM; also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells; directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression; YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro; suppresses the growth of GBM xenografts in vivo.
CAS Number
1643120-60-8
Product Name Alternative
YZ-129 | YZ 129
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 5.6 mg/mL (18.65 mM)
Smiles
O=C (C1=CC=CC=C1C (NC2=CC=C (C=NC=C3) C3=C2) =C4) C4=O
Molecular Formula
C19H12N2O2
Molecular Weight
300.317
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (isoquinolin-6-ylamino) naphthalene-1,2-dione

Chemical Information

4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione
CAS Number1643120-60-8
PubChem CID137628683
IUPAC Name4-(isoquinolin-6-ylamino)naphthalene-1,2-dione
Molecular FormulaC19H12N2O2
Molecular Weight300.3
XLogP2.9
Topological Polar Surface Area59.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity527
SMILES
C1=CC=C2C(=C1)C(=CC(=O)C2=O)NC3=CC4=C(C=C3)C=NC=C4
InChI
InChI=1S/C19H12N2O2/c22-18-10-17(15-3-1-2-4-16(15)19(18)23)21-14-6-5-13-11-20-8-7-12(13)9-14/h1-11,21H
InChIKey
NYDMVPHEEBVAHT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione
CAS: 1643120-60-8
CID: 137628683
Formula: C19H12N2O2
MW: 300.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight300.3
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass300.089877630
Monoisotopic Mass300.089877630
Topological Polar Surface Area59.1 Ų
Heavy Atom Count23
Formal Charge0
Complexity527
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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MBS387939-01YZ129
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A13601-2YZ129 2mg
A13601-100YZ129 100mg
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A13601-1YZ129 1mg
A13601-50YZ129 50mg
A13601-10YZ129 10mg

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