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YZ129

CAT: 0013-GTR19217387-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217387-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM; also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells; directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression; YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro; suppresses the growth of GBM xenografts in vivo.
CAS Number
1643120-60-8
Product Name Alternative
YZ-129 | YZ 129
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 5.6 mg/mL (18.65 mM)
Smiles
O=C (C1=CC=CC=C1C (NC2=CC=C (C=NC=C3) C3=C2) =C4) C4=O
Molecular Formula
C19H12N2O2
Molecular Weight
300.317
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (isoquinolin-6-ylamino) naphthalene-1,2-dione

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