Products for Research Use Only
RegisterLogin

Asciminib hydrochloride

CAT: 0013-GTR19217025-01Size: 500 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19217025-01Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Asciminib (ABL001) hydrochloride binds to the myristoyl pocket of ABL1 and induces the formation of an inactive kinase conformation.Asciminib hydrochloride binds potently (dissociation constant=0.5-0.8 nM) and selectively to the myristoyl pocket of ABL1 and induces the inactive C-terminal helix conformation. Asciminib hydrochloride exhibits the same non-ATP-competitive biochemical kinetics as the BCR–ABL inhibitor GNF-2 but with approximately 100-fold greater potency.Asciminib hydrochloride lacks activity against more than 60 kinases, including SRC, and is similarly inactive against G-protein-coupled receptors, ion channels, nuclear receptors and transporters.
CAS Number
2119669-71-3
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL (205.63 mM; Need ultrasonic) ; H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
Smiles
O=C (NC1=CC=C (C=C1) OC (Cl) (F) F) C2=CC (C3=NNC=C3) =C (N=C2) N4C[C@@H] (CC4) O.[H]Cl
Molecular Formula
C20H19Cl2F2N5O3
Molecular Weight
486.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Related Products

CatalogName
GTR19163122-01Asciminib
GTR19168577-01Asciminib
GTR19277077-01Asciminib-NH2
GTR19224924-01NSC10010 hydrochloride
GTR19251079-01Tryptamine hydrochloride
GTR19250781Azetidine hydrochloride
GTR19157452-01Benzamil (hydrochloride)
GTR19157233-01Imeglimin hydrochloride
GTR19156886-01Propranolol hydrochloride
GTR19156853-01Dopexamine hydrochloride

Alternative Products

CatalogName
MBS5805901Asciminib hydrochloride
HY-104010A-01Asciminib (hydrochloride)
MBS133343Asciminib
AR-A07169-01(S) -Asciminib
C13491-100mgAsciminib (ABL001)
CS-O-59032Asciminib-d4

Popular Products