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Lodoxamide tromethamine

CAT: 0013-GTR19216852-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216852-01Size:500 mg
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Description
Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis. (In Vitro) :In purified rat peritoneal mast cells, Lodoxamide tromethamine inhibits ionophore-induced 45Ca influx with associated histamine release. Lodoxamide tromethamine significantly and dose-dependently inhibits the chemotactic response of eosinophils to fMLP and to IL-5. Lodoxamide tromethamine strongly inhibits the release of eosinophil peroxidase after IgA-dependent activation and inhibits the release of eosinophil cationic protein and eosinophil-derived neurotoxin to a lesser extent. (In Vivo) :In Ascaris-sensitized anesthetized rhesus monkeys, Lodoxamide tromethamine significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge. The addition of Lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution increases oxygenation, decreases microvascular permeability, and increases compliance thereby decreasing lung reperfusion injury.
CAS Number
63610-09-3
Product Name Alternative
U-42585E
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: H2O : ≥ 100 mg/mL (180.54 mM) )
Smiles
NC (CO) (CO) CO.NC (CO) (CO) CO.OC (=O) C (=O) Nc1cc (cc (NC (=O) C (O) =O) c1Cl) C#N
Molecular Formula
C19H28ClN5O12
Molecular Weight
553.91
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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Alternative Products

CatalogName
HY-16289-01Lodoxamide (tromethamine)
MBS3615357-01Lodoxamide tromethamine
A17969-5Lodoxamide Tromethamine 5mg
HY-16289R-01Lodoxamide (tromethamine) (Standard)
A17969-100Lodoxamide Tromethamine 100mg
A17969-25Lodoxamide Tromethamine 25mg
A17969-10Lodoxamide Tromethamine 10mg
A17969-200Lodoxamide Tromethamine 200mg
A17969-50Lodoxamide Tromethamine 50mg
A17969-10mM-DLodoxamide Tromethamine 10mM * 1mL in DMSO

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