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Fosfomycin Tromethamine

CAT: 0013-GTR19158837-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158837-01Size:500 mg
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Description
An antibiotic produced by Streptomyces fradiae. (In Vitro) :Fosfomycin sodium is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis.Fosfomycin sodium has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%.Fosfomycin sodium displays extensive tissue penetration, can be used to research of infections of the CNS, soft tissues, bone, lungs, and abscesses. (In Vivo) :Fosfomycin sodium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes.
CAS Number
78964-85-9
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:196.8 mM; Water:196.8 mM
Smiles
C[C@@H]1O[C@@H]1P (O) (O) =O.NC (CO) (CO) CO
Molecular Formula
C7H18NO7P
Molecular Weight
259.19
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Fosfomycin Tromethamine

Fosfomycin tromethamine is a phosphonoacetic acid.

CAS Number78964-85-9
PubChem CID10199068
IUPAC Name2-amino-2-(hydroxymethyl)propane-1,3-diol;[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid
Molecular FormulaC7H18NO7P
Molecular Weight259.19
Topological Polar Surface Area157
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count16
Formal Charge0
Complexity192
SMILES
C[C@H]1[C@H](O1)P(=O)(O)O.C(C(CO)(CO)N)O
InChI
InChI=1S/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8;1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2;2-3H,1H3,(H2,4,5,6)/t;2-,3+/m.0/s1
InChIKey
QZJIMDIBFFHQDW-LMLSDSMGSA-N
Chemical Structure
2D Structure
2D structure of Fosfomycin Tromethamine
CAS: 78964-85-9
CID: 10199068
Formula: C7H18NO7P
MW: 259.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight259.19
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass259.08208891
Monoisotopic Mass259.08208891
Topological Polar Surface Area157 Ų
Heavy Atom Count16
Formal Charge0
Complexity192
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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