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Methotrexate metabolite

CAT: 0013-GTR19216848-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19216848-01Size:1 g
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Description
Methotrexate metabolite is the active metabolite of Methotrexate which is a folic acid antagonist. Methotrexate metabolite inhibits parasite growth. (In Vitro) :Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR) .
CAS Number
19741-14-1
Product Name Alternative
DAMPA
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 5 mg/mL (15.37 mM)
Smiles
CN (Cc1cnc2nc (N) nc (N) c2n1) c1ccc (cc1) C (O) =O
Molecular Formula
C15H15N7O2
Molecular Weight
325.332
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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