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ALC-0366

CAT: 0013-GTR19216104-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216104-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALC 0366 is an ionizable cationic lipid (pKa = 6.25) from Biontech, which is derived from ALC-0315. ALC0366 has been used as a key component of LNP to deliver BNT142, a lipid nanoparticle (LNP) -formulated RNA (RNA-LNP) encoding a T cell-engaging bispecific antibody that monovalently binds the T cell marker CD3 and bivalently binds claudin 6 (CLDN6), an oncofetal antigen that is absent from normal adult tissue but expressed on various solid tumors.
CAS Number
2096984-25-5
Purity
>95%
Smiles
OCCCN (CCCCCCCCCOC (C (CCCC) CCCCCC) =O) CCCCCCCCCOC (C (CCCC) CCCCCC) =O
Molecular Formula
C45H89NO5
Molecular Weight
724.2
Notes
For research use only.

Chemical Information

1,1'-(((3-Hydroxypropyl)imino)di-9,1-nonanediyl) bis(2-butyloctanoate)
CAS Number2096984-25-5
PubChem CID129087064
IUPAC Name9-[9-(2-butyloctanoyloxy)nonyl-(3-hydroxypropyl)amino]nonyl 2-butyloctanoate
Molecular FormulaC45H89NO5
Molecular Weight724.2
XLogP15.8
Topological Polar Surface Area76.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count43
Heavy Atom Count51
Formal Charge0
Complexity675
SMILES
CCCCCCC(CCCC)C(=O)OCCCCCCCCCN(CCCCCCCCCOC(=O)C(CCCC)CCCCCC)CCCO
InChI
InChI=1S/C45H89NO5/c1-5-9-13-25-34-42(32-11-7-3)44(48)50-40-29-23-19-15-17-21-27-36-46(38-31-39-47)37-28-22-18-16-20-24-30-41-51-45(49)43(33-12-8-4)35-26-14-10-6-2/h42-43,47H,5-41H2,1-4H3
InChIKey
WKWZZCCOOBPOOA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,1'-(((3-Hydroxypropyl)imino)di-9,1-nonanediyl) bis(2-butyloctanoate)
CAS: 2096984-25-5
CID: 129087064
Formula: C45H89NO5
MW: 724.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight724.2
XLogP315.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count43
Exact Mass723.67407494
Monoisotopic Mass723.67407494
Topological Polar Surface Area76.1 Ų
Heavy Atom Count51
Formal Charge0
Complexity675
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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