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CL4F8-6

CAT: 0013-GTR19216103Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19216103Size:25 mg
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Description
CL4F8-6 is an ionizable cationic lipid (pKa = 6.14) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) .1 LNPs containing CL4F8-6 and encapsulating an mRNA reporter accumulate specifically in the mouse liver after intravenous administration. LNPs containing CL4F8-6 and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA (sgRNA) targeting Ttr (sgTtr), the gene encoding transthyretin, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum levels of TTR.
CAS Number
2766493-12-1
Purity
>95%
Smiles
C (O) (CCCCCCOC (=O) C (CCCCCC) CCCCCC) (CCCCCCOC (=O) C (CCCCCC) CCCCCC) CCCCN (CCC) CCC
Molecular Formula
C51H101NO5
Molecular Weight
808.35
Notes
For research use only.

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