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JC2-11

CAT: 0013-GTR19213570-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213570-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JC2-11 is a small molecule inhibitor that suppresses inflammasome activation by targeting NLRC4 and AIM2 pathways. It disrupts ROS production and caspase-1 activity, thereby reducing GSDMD cleavage, IL-1β maturation, and LDH release. This compound is a valuable research tool for studying pyroptosis and inflammation in both cellular and animal models of inflammatory diseases.
CAS Number
937820-89-8
Product Name Alternative
LDH, NODlikeReceptor (NLR), NODlikeReceptor, NOD-like Receptor (NLR), NOD-like Receptor, NODlike Receptor (NLR), NLR, JC211, JC2-11, IL Receptor, IL-1β, ILReceptor, Caspase-1, AIM2, ROS
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry
Purity
98.60% (May vary between batches)
Solubility
DMSO:127.5 mg/mL (421.77 mM)
Smiles
C (/C=C/C1=CC (OC) =C (O) C=C1) (=O) C2=CC (F) =C (OC) C=C2
Molecular Formula
C17H15FO4
Molecular Weight
302.3
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(E)-1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
CAS Number937820-89-8
PubChem CID24895134
IUPAC Name(E)-1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
Molecular FormulaC17H15FO4
Molecular Weight302.30
XLogP3.4
Topological Polar Surface Area55.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count22
Formal Charge0
Complexity398
SMILES
COC1=C(C=C(C=C1)C(=O)/C=C/C2=CC(=C(C=C2)O)OC)F
InChI
InChI=1S/C17H15FO4/c1-21-16-8-5-12(10-13(16)18)14(19)6-3-11-4-7-15(20)17(9-11)22-2/h3-10,20H,1-2H3/b6-3+
InChIKey
YYAIFDXWRNNHAW-ZZXKWVIFSA-N
Chemical Structure
2D Structure
2D structure of (E)-1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
CAS: 937820-89-8
CID: 24895134
Formula: C17H15FO4
MW: 302.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight302.30
XLogP33.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass302.09543712
Monoisotopic Mass302.09543712
Topological Polar Surface Area55.8 Ų
Heavy Atom Count22
Formal Charge0
Complexity398
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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