Muvalaplin

CAT: 0013-GTR19214013-02Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19214013-02Size:25 mg

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Description

Muvalaplin (LY3473329) is an orally bioavailable small molecule inhibitor of lipoprotein (a) [Lp (a) ] synthesis. It functions by disrupting the intracellular interaction between apolipoprotein (a) and apolipoprotein B-100, thereby reducing Lp (a) assembly. This mechanism supports its use in cardiovascular disease research, with studies demonstrating Lp (a) -lowering effects in both in vitro models and clinical trials.

CAS Number

2565656-70-2

Product Name Alternative

LY3473329, LY-3473329, LY 3473329, Lipoprotein (a), Muvalaplin

Field of Research

Metabolism Research

Purity

97.76% (May vary between batches)

Solubility

H2O:<0.1 mg/mL; DMSO:10 mg/mL (14.07 mM)

Smiles

[C@@H] (CC1=CC (CN (CC2=CC (C[C@H] (C (O) =O) [C@]3 (CCNC3) [H]) =CC=C2) CC4=CC (C[C@H] (C (O) =O) [C@]5 (CCNC5) [H]) =CC=C4) =CC=C1) (C (O) =O) [C@]6 (CCNC6) [H]

Molecular Formula

C42H54N4O6

Molecular Weight

710.9

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Muvalaplin

Muvalaplin is a small molecule drug. Muvalaplin is under investigation in clinical trial NCT05563246 (A Study of LY3473329 in Adult Participants With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events). Muvalaplin has a monoisotopic molecular weight of 710.4 Da.

CAS Number	2565656-70-2
PubChem CID	155369486
IUPAC Name	(2S)-3-[3-[[bis[[3-[(2S)-2-carboxy-2-[(3R)-pyrrolidin-3-yl]ethyl]phenyl]methyl]amino]methyl]phenyl]-2-[(3R)-pyrrolidin-3-yl]propanoic acid
Molecular Formula	C42H54N4O6
Molecular Weight	710.9
XLogP	-2.8
Topological Polar Surface Area	151
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	18
Heavy Atom Count	52
Formal Charge	0
Complexity	1020

SMILES

C1CNC[C@H]1[C@H](CC2=CC(=CC=C2)CN(CC3=CC=CC(=C3)C[C@@H]([C@H]4CCNC4)C(=O)O)CC5=CC=CC(=C5)C[C@@H]([C@H]6CCNC6)C(=O)O)C(=O)O

InChI

InChI=1S/C42H54N4O6/c47-40(48)37(34-10-13-43-22-34)19-28-4-1-7-31(16-28)25-46(26-32-8-2-5-29(17-32)20-38(41(49)50)35-11-14-44-23-35)27-33-9-3-6-30(18-33)21-39(42(51)52)36-12-15-45-24-36/h1-9,16-18,34-39,43-45H,10-15,19-27H2,(H,47,48)(H,49,50)(H,51,52)/t34-,35-,36-,37-,38-,39-/m0/s1

InChIKey

BRLGERLDHZRETI-BGBFCPIGSA-N

Chemical Structure

2D Structure

CAS: 2565656-70-2

CID: 155369486

Formula: C42H54N4O6

MW: 710.9

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	710.9
XLogP3	-2.8
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	18
Exact Mass	710.40433546
Monoisotopic Mass	710.40433546
Topological Polar Surface Area	151 Å²
Heavy Atom Count	52
Formal Charge	0
Complexity	1020
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
M37059-01	Muvalaplin
HY-46749-01	Muvalaplin (tetrahydrochloride)
E1691-01	Muvalaplin (LY3473329)
T200452-01	Muvalaplin tetrahydrochloride

Muvalaplin

Chemical Information

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