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Muvalaplin

CAT: 1410-M37059-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M37059-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Muvalaplin (LY3473329) is an orally active lipoprotein (a) [Lp (a) ] reagent that inhibits Lp (a) formation by blocking apo (a) -apo B100 interactions.
CAS Number
2565656-70-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
710.9
Molecular Formula
C42H54N4O6
Notes
Research use only, not for human use.
Receptor
Others

Chemical Information

Muvalaplin

Muvalaplin is a small molecule drug. Muvalaplin is under investigation in clinical trial NCT05563246 (A Study of LY3473329 in Adult Participants With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events). Muvalaplin has a monoisotopic molecular weight of 710.4 Da.

CAS Number2565656-70-2
PubChem CID155369486
IUPAC Name(2S)-3-[3-[[bis[[3-[(2S)-2-carboxy-2-[(3R)-pyrrolidin-3-yl]ethyl]phenyl]methyl]amino]methyl]phenyl]-2-[(3R)-pyrrolidin-3-yl]propanoic acid
Molecular FormulaC42H54N4O6
Molecular Weight710.9
XLogP-2.8
Topological Polar Surface Area151
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count18
Heavy Atom Count52
Formal Charge0
Complexity1020
SMILES
C1CNC[C@H]1[C@H](CC2=CC(=CC=C2)CN(CC3=CC=CC(=C3)C[C@@H]([C@H]4CCNC4)C(=O)O)CC5=CC=CC(=C5)C[C@@H]([C@H]6CCNC6)C(=O)O)C(=O)O
InChI
InChI=1S/C42H54N4O6/c47-40(48)37(34-10-13-43-22-34)19-28-4-1-7-31(16-28)25-46(26-32-8-2-5-29(17-32)20-38(41(49)50)35-11-14-44-23-35)27-33-9-3-6-30(18-33)21-39(42(51)52)36-12-15-45-24-36/h1-9,16-18,34-39,43-45H,10-15,19-27H2,(H,47,48)(H,49,50)(H,51,52)/t34-,35-,36-,37-,38-,39-/m0/s1
InChIKey
BRLGERLDHZRETI-BGBFCPIGSA-N
Chemical Structure
2D Structure
2D structure of Muvalaplin
CAS: 2565656-70-2
CID: 155369486
Formula: C42H54N4O6
MW: 710.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight710.9
XLogP3-2.8
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count18
Exact Mass710.40433546
Monoisotopic Mass710.40433546
Topological Polar Surface Area151 Ų
Heavy Atom Count52
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP01604-01Muvalaplin
HY-46749-01Muvalaplin (tetrahydrochloride)
GTR19238927-01Muvalaplin tetrahydrochloride
E1691-01Muvalaplin (LY3473329)
GTR19216182-01LY3473329 (Muvalaplin)

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