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P53 Activator 7

CAT: 0013-GTR19213468-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19213468-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P53 Activator 7 is a potent, cell-permeable small molecule that selectively stabilizes and reactivates the p53 Y220C mutant protein, triggering apoptotic cell death. Its application in cancer research includes in vitro studies in mutant p53 cell lines and in vivo proof-of-concept models investigating tumor suppression.
CAS Number
2849340-59-4
Product Name Alternative
Apoptosis, MDM-2/p53
Field of Research
Cancer Biology, Cell Biology
Purity
98.16% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.39 mM) ; DMSO:80 mg/mL (154.88 mM)
Smiles
O=P (C1=CC=C (C=C1) NCC#CC2=CC=3C (=CC=CC3N2CC (F) (F) F) NC4CCN (C) CC4) (C) C
Molecular Formula
C27H32F3N4OP
Molecular Weight
516.538
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

p53 Activator 7
CAS Number2849340-59-4
PubChem CID166176923
IUPAC Name2-[3-(4-dimethylphosphorylanilino)prop-1-ynyl]-N-(1-methylpiperidin-4-yl)-1-(2,2,2-trifluoroethyl)indol-4-amine
Molecular FormulaC27H32F3N4OP
Molecular Weight516.5
XLogP4.5
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count36
Formal Charge0
Complexity833
SMILES
CN1CCC(CC1)NC2=C3C=C(N(C3=CC=C2)CC(F)(F)F)C#CCNC4=CC=C(C=C4)P(=O)(C)C
InChI
InChI=1S/C27H32F3N4OP/c1-33-16-13-21(14-17-33)32-25-7-4-8-26-24(25)18-22(34(26)19-27(28,29)30)6-5-15-31-20-9-11-23(12-10-20)36(2,3)35/h4,7-12,18,21,31-32H,13-17,19H2,1-3H3
InChIKey
TWHPNHHZQSJOEI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of p53 Activator 7
CAS: 2849340-59-4
CID: 166176923
Formula: C27H32F3N4OP
MW: 516.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight516.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass516.22658314
Monoisotopic Mass516.22658314
Topological Polar Surface Area49.3 Ų
Heavy Atom Count36
Formal Charge0
Complexity833
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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