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P53 Activator 17

CAT: 0013-GTR19274317-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274317-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P53 Activator 17 is an activator of p53-Y220C. It exhibits selective cytotoxicity and pro-apoptotic (apoptosis) activity in cancer cell lines with the p53-Y220C mutation, with minimal effects on wild-type or p53-null cells. This compound promotes the conversion of intracellular p53-Y220C from a mutant to a wild-type conformation, activating the transcription of classic p53 target genes, including BBC3 (PUMA) and MDM2. p53 Activator 17 is applicable for research on hepatocellular carcinoma and breast cancer.
Storage Conditions
-20°C
Notes
For research use only.

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