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FGFR4-IN-8

CAT: 0013-GTR19212373-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19212373-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGFR4-IN-8 is a highly selective, ATP-competitive covalent inhibitor effective against wild-type and gatekeeper mutant FGFR4 (IC50: 0.5-1.6 nM) . It demonstrates potent antiproliferative activity in Hep3B cells (IC50: 29 nM) and shows moderate antitumor efficacy in Huh-7 xenograft models, supporting its use in FGFR4-driven cancer research.
CAS Number
2765240-52-4
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
C[C@H] (C1=C (C=NC=C1Cl) Cl) OC2=CC3=C (C=C2) NN=C3NC4=C (C=C (C=C4F) N5CCC (CC5) N6CCOCC6) NC (=O) C=C
Molecular Formula
C32H34Cl2FN7O3
Molecular Weight
654.56
Storage Conditions
-20°C
Notes
For research use only.

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